Finding the key to open the blood brain barrier (The Dana Foundation Website – 5 December 2011)
Potential drugs for neurodegenerative disorders such as multiple sclerosis (MS) and Alzheimer’s disease have been stymied by their inability to cross the blood brain barrier (BBB), a system of unique blood vessels that acts as a natural barricade between the brain and the rest of the body. This barrier, designed to block potentially harmful substances from reaching neural tissue, also holds back the very agents designed to target disease. But two new techniques, one using endogenous adenosine receptors and another using ultrasound, may offer doctors the ability to not only open the BBB but also control the length of time it remains open…
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